../_images/nederland21.jpg

bijwerkingen clozapine


Table 10. Adverse Reactions (≥2%) Reported in CLOZARIL-treated Patients (N=842) Across all CLOZARIL Studies (excluding the 2-year InterSePTTM Study)

Body System Adverse Reaction*

CLOZARIL

N=842

Percentage of Patients

Body System Adverse Reaction*

Central Nervous System:

  1. Drowsiness/Sedation 39

  2. Dizziness/Vertigo 19

  3. Headache 7

  4. Tremor 6

  5. Syncope 6

  6. Disturbed Sleep/Nightmares 4

  7. Restlessness 4

  8. Hypokinesia/Akinesia 4

  9. Agitation 4

  10. Seizures (convulsions) 3†

  11. Rigidity 3

  12. Akathisia 3

  13. Confusion 3

  14. Fatigue 2

  15. Insomnia 2

Cardiovascular:

  1. Tachycardia 25†

  2. Hypotension 9

  3. Hypertension 4

Gastrointestinal:

  1. Constipation 14

  2. Nausea 5

  3. Abdominal Discomfort/Heartburn 4

  4. Nausea/Vomiting3

  5. Vomiting 3

  6. Diarrhea 2

Urogenital:

  1. Urinary Abnormalities 2

Autonomic Nervous System:

  1. Salivation 31

  2. Sweating 6

  3. Dry Mouth 6

  4. Visual Disturbances 5

Skin:

  1. Rash 2

Hemic/Lymphatic:

  1. Leukopenia/Decreased WBC/Neutropenia 3

Miscellaneous:

  1. Fever 4

  2. Weight Gain 5

†Rate based on population of approximately 1700 exposed during premarket clinical evaluation of CLOZARIL.


home - manual - source - about